CovidV1, Main, Exploration, bibRecord, 000C70

Drosophila as a genetic model for studying pathogenic human viruses

Identifieur interne : 000C70 ( Main/Exploration ); précédent : 000C69; suivant : 000C71

Drosophila as a genetic model for studying pathogenic human viruses

Auteurs : Tamara T. Hughes ; Amanda L. Allen ; Joseph E. Bardin ; Megan N. Christian ; Kansei Daimon ; Kelsey D. Dozier ; Caom L. Hansen ; Lisa M. Holcomb ; Joseph Ahlander

Source :

Virology [ 0042-6822 ] ; 2011.

RBID : PMC:3253880

Abstract

Viruses are infectious particles whose viability is dependent on the cells of living organisms, such as bacteria, plants, and animals. It is of great interest to discover how viruses function inside host cells in order to develop therapies to treat virally infected organisms. The fruit fly Drosophila melanogaster is an excellent model system for studying the molecular mechanisms of replication, amplification, and cellular consequences of human viruses. In this review, we describe the advantages of using Drosophila as a model system to study human viruses, and highlight how Drosophila has been used to provide unique insight into the gene function of several pathogenic viruses. We also propose possible directions for future research in this area.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253880

DOI: 10.1016/j.virol.2011.11.016
PubMed: 22177780
PubMed Central: 3253880

Affiliations:

Le document en format XML

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<series><title level="j">Virology</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">Viruses are infectious particles whose viability is dependent on the cells of living organisms, such as bacteria, plants, and animals. It is of great interest to discover how viruses function inside host cells in order to develop therapies to treat virally infected organisms. The fruit fly <italic>Drosophila melanogaster</italic>
 is an excellent model system for studying the molecular mechanisms of replication, amplification, and cellular consequences of human viruses. In this review, we describe the advantages of using <italic>Drosophila</italic>
 as a model system to study human viruses, and highlight how <italic>Drosophila</italic>
 has been used to provide unique insight into the gene function of several pathogenic viruses. We also propose possible directions for future research in this area.</p>
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<name sortKey="Bardin, Joseph E" sort="Bardin, Joseph E" uniqKey="Bardin J" first="Joseph E." last="Bardin">Joseph E. Bardin</name>
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<name sortKey="Hughes, Tamara T" sort="Hughes, Tamara T" uniqKey="Hughes T" first="Tamara T." last="Hughes">Tamara T. Hughes</name>
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Drosophila as a genetic model for studying pathogenic human viruses

Drosophila as a genetic model for studying pathogenic human viruses

Source :

Abstract

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Le document en format XML

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